CONSERVED SYNTENY BETWEEN PIG CHROMOSOME-8 AND HUMAN CHROMOSOME-4 BUT REARRANGED AND DISTORTED LINKAGE MAPS

被引：30

作者：

ELLEGREN, H ^{[1
]}

FREDHOLM, M ^{[1
]}

EDFORSLILJA, I ^{[1
]}

WINTERO, AK ^{[1
]}

ANDERSSON, L ^{[1
]}

机构：

[1] ROYAL VET & AGR UNIV, DIV ANIM GENET, DEPT ANIM PROD & ANIM HLTH, DK-1870 FREDERIKSBERG C, DENMARK

来源：

GENOMICS | 1993年 / 17卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1378

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The porcine genes encoding interleukin 2, alcohol dehydrogenase (class I) gamma polypeptide, and osteopontin were mapped to chromosome 8 by linkage analysis. Together with previous assignments to this chromosome (the albumin, platelet-derived growth factor receptor A, and fibrinogen genes), an extensive syntenic homology with human chromosome 4 was discovered. Loci from about three-quarters of the q arm of human chromosome 4 are on pig chromosome 8. However, the linear order of the markers is not identical in the two species, and there are several examples of interspecific differences in the recombination fractions between adjacent markers. The conserved synteny between man and the pig gives strong support to a previous suggestion that a synteny group present in the ancestor of mammalian species has been retained on human chromosome 4q. Since loci from this synteny group are found on two cattle chromosomes, the bovine rearrangement must have occurred after the split of Suidae and Bovidae within Artiodactyla. © 1993 Academic Press, Inc.

引用

页码：599 / 603

页数：5

共 29 条

[1]

Archibald A. L., 1992, ANIM GENET S1, V23, P88

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