RECOVERY FROM EXPERIMENTAL PARKINSONISM IN PRIMATES WITH GM1 GANGLIOSIDE TREATMENT

被引：186

作者：

SCHNEIDER, JS ^{[1
]}

POPE, A ^{[1
]}

SIMPSON, K ^{[1
]}

TAGGART, J ^{[1
]}

SMITH, MG ^{[1
]}

DISTEFANO, L ^{[1
]}

机构：

[1] HAHNEMANN UNIV, SCH MED, INST NEUROSCI, PHILADELPHIA, PA 19102 USA

来源：

SCIENCE | 1992年 / 256卷 / 5058期

关键词：

D O I：

10.1126/science.1350379

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A parkinsonian syndrome can be produced in nonhuman primates by administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Parkinsonian-like symptoms induced acutely by MPTP were ameliorated after treatment with G(M1) ganglioside, a substance shown to have neurotrophic effects on the damaged dopamine system in rodents. Treatment with G(M)1 ganglioside also increased striatal dopamine and metabolite levels and enhanced the dopaminergic innervation of the striatum as demonstrated by tyrosine hydroxylase immunohistochemistry. These results suggest that G(M1) ganglioside may hold promise as a therapeutic agent for the treatment of Parkinson's disease.

引用

页码：843 / 846

页数：4

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