THE EFFICACY OF MUPIROCIN OINTMENT AND CHLORHEXIDINE BODY SCRUBS IN THE ERADICATION OF NASAL CARRIAGE OF STAPHYLOCOCCUS-AUREUS AMONG PATIENTS UNDERGOING LONG-TERM HEMODIALYSIS

被引：36

作者：

WATANAKUNAKORN, C

BRANDT, J

DURKIN, P

SANTORE, S

BOTA, B

STAHL, CJ

机构：

[1] Infectious Disease Section, the Infection Control Services, St. Elizabeth Hospital Medical Center, Youngstown

[2] the Northeastern Ohio Universities College of Medicine, Rootstown

来源：

AMERICAN JOURNAL OF INFECTION CONTROL | 1992年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0196-6553(05)80180-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Patients undergoing long-term hemodialysis have a high prevalence of Staphylococcus aureus nasal carriage, which may lead to serious infections. Mupirocin ointment has been used intranasally to eradicate S. aureus carriage in health human volunteers and health care workers. Chlorhexidine, an antiseptic with excellent antistaphylococcal activity, is widely used for handwashing and skin cleansing. Methods: Anterior nares cultures were obtained from patients older than 18 years who were undergoing long-term hemodialysis. Patients with S. aureus nasal carriage were enrolled in the study. Axillae and groins were cultured. Patients were given mupirocin ointment intranasally twice per day for 7 days and chlorhexidine body scrubs daily for the first 3 days. Follow-up cultures were obtained from anterior nares, axillae, and groins at 1 day, and 1, 4, 8 and 12 weeks after treatment. Results: One day after completion of treatment nasal carriage was eradicated in 83% of patients (15/18). After 12 weeks, 69% of patients (11/16) were free of nasal carriage. Conclusions: Success rates of eradication were excellent compared with those in other published reports. This simple and effective regimen had no major side effects.

引用

页码：138 / 141

页数：4

共 20 条

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