ACUTE DEMYELINATING DISEASE - CLASSIFICATION AND NONINVASIVE DIAGNOSIS

被引：98

作者：

POSER, S ^{[1
]}

LUER, W ^{[1
]}

BRUHN, H ^{[1
]}

FRAHM, J ^{[1
]}

BRUCK, Y ^{[1
]}

FELGENHAUER, K ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,W-3400 GOTTINGEN,GERMANY

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1992年 / 86卷 / 06期

关键词：

MULTIPLE SCLEROSIS; SCHILDERS DISEASE; MARBURGS DISEASE; MAGNETIC RESONANCE; SPECTROSCOPY; BRAIN BIOPSY;

D O I：

10.1111/j.1600-0404.1992.tb05490.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Five young patients are described with biopsy-proven acute demyelinating disease. Two cases are classified as Schilder's disease, a particular childhood form of multiple sclerosis (MS) with atypical clinical manifestation, normal or atypical CSF-findings and large bilateral lesions in magnetic resonance imaging (MRI). Two further cases presented with a fulminant bout of MS with typical clinical picture and CSF-findings; they are classified as Marburg's disease. The last case was an acute second bout of classical MS. The biopsy seemed to be justified in 4 cases, but unnecessary in the last case. Localized proton magnetic resonance spectroscopy (MRS) performed in one case allowed us to examine the focal cerebral abnormalities directly and non-invasively. The spectra revealed a pattern typical of acute demyelination suggesting potential for a replacement of biopsy in the future.

引用

页码：579 / 585

页数：7

共 29 条

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