MEASUREMENT OF GENE MUTATION IN-VIVO USING MUTA(TM)MOUSE AND POSITIVE SELECTION FOR LACZ(-) PHAGE

被引：60

作者：

DEAN, SW ^{[1
]}

MYHR, B ^{[1
]}

机构：

[1] HAZLETON WASHINGTON INC, VIENNA, VA 22182 USA

来源：

MUTAGENESIS | 1994年 / 9卷 / 03期

关键词：

D O I：

10.1093/mutage/9.3.183

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The use of transgenic animals for in vivo mutagenicity studies following rescue of the bacterial lacZ transgene has been hindered by the sheer scale of the experimental work involved. We describe here a new positive selection protocol which is based upon a modified E. coli bacterial host. This new system is potentially capable of generating mutation data much faster and more cheaply than previous methods.

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页码：183 / 185

页数：3

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