THE IMMUNOMODULATORY EFFECTS OF LEVAMISOLE ON RAINBOW-TROUT, ONCORHYNCHUS-MYKISS

被引：203

作者：

KAJITA, Y

SAKAI, M

ATSUTA, S

KOBAYASHI, M

机构：

[1] School of Fisheries Sciences, Kitasato University, Sanriku, Iwate

来源：

FISH PATHOLOGY | 1990年 / 25卷 / 02期

关键词：

D O I：

10.3147/jsfp.25.93

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The immunomodulatory effects of levamisole were investigated using rainbow trout, Oncor hynchus mykiss. Fish sampled 5 days after intraperitoneal injection of levamisole showed in creased protection against Vibrio anguillarum when a single dose (0.5 mg/kg) was used. Phago cytic activity, chemiluminescence responses and natural killer cell activity in fish treated with levamisole were also increased, compared with those in the saline treated fish. Furthermore, levamisole activated the alternative complement pathway of rainbow trout, although serum bacteri cidal activities against V. anguillarum were not enhanced by the treatment of levamisole. These results indicate that levamisole has immunomodulatory effects in rainbow trout. © 1990 Japanese Society of Fish Pathology. All rights reserved.

引用

页码：93 / 98

页数：6

共 16 条

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