BIOSYNTHESIS OF THE HYPOCHOLESTEROLEMIC AGENT MEVINOLIN BY ASPERGILLUS-TERREUS - DETERMINATION OF THE ORIGIN OF CARBON, HYDROGEN, AND OXYGEN-ATOMS BY C-13-NMR AND MASS-SPECTROMETRY

被引：128

作者：

MOORE, RN ^{[1
]}

BIGAM, G ^{[1
]}

CHAN, JK ^{[1
]}

HOGG, AM ^{[1
]}

NAKASHIMA, TT ^{[1
]}

VEDERAS, JC ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1985年 / 107卷 / 12期

关键词：

D O I：

10.1021/ja00298a046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：3694 / 3701

页数：8

共 153 条

[1] BIOSYNTHESIS OF THE POLYKETIDE MELLEIN FROM CD3CO2H AND (CD3CO2H)-C-13 IN ASPERGILLUS-MELLEUS - DETECTION OF DEUTERIUM BY H-2 NMR AND EDITED C-13 NMR-SPECTRA
ABELL, C
DODDRELL, DM
GARSON, MJ
LAUE, ED
STAUNTON, J
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1983, (12) : 694 - 696
[2] AJAZ AA, 1983, J CHEM SOC CHEM COMM, P679, DOI 10.1039/c39830000679
[3] DIHYDROMEVINOLIN, A POTENT HYPOCHOLESTEROLEMIC METABOLITE PRODUCED BY ASPERGILLUS-TERREUS
ALBERSSCHONBERG, G
JOSHUA, H
LOPEZ, MB
HENSENS, OD
SPRINGER, JP
CHEN, J
OSTROVE, S
HOFFMAN, CH
ALBERTS, AW
PATCHETT, AA
[J]. JOURNAL OF ANTIBIOTICS, 1981, 34 (05) : 507 - 512
[4] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT
ALBERTS, AW
CHEN, J
KURON, G
HUNT, V
HUFF, J
HOFFMAN, C
ROTHROCK, J
LOPEZ, M
JOSHUA, H
HARRIS, E
PATCHETT, A
MONAGHAN, R
CURRIE, S
STAPLEY, E
ALBERSSCHONBERG, G
HENSENS, O
HIRSHFIELD, J
HOOGSTEEN, K
LIESCH, J
SPRINGER, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07): : 3957 - 3961
[5] ALBERTS AW, 1984, FATTY ACID METABOLIS, P29
[6] ALVAREZ G, 1983, J ORG CHEM, V48, P5123
[7] SYNTHETIC STUDIES RELATED TO COMPACTIN AND MEVINOLIN - A NEW SYNTHESIS OF THE HEXAHYDRONAPHTHALENE PORTION OF COMPACTIN
ANDERSON, PC
CLIVE, DLJ
EVANS, CF
[J]. TETRAHEDRON LETTERS, 1983, 24 (13) : 1373 - 1376
[8] STEREOCHEMISTRY OF THE REACTIONS CATALYZED BY CHICKEN LIVER FATTY-ACID SYNTHASE
ANDERSON, VE
HAMMES, GG
[J]. BIOCHEMISTRY, 1984, 23 (09) : 2088 - 2094
[9] BIOSYNTHESIS OF NON-ACTIN FROM ACETATE, PROPIONATE, AND SUCCINATE - THE ASSIGNMENT OF ITS C-13 NMR-SPECTRUM BY TWO-DIMENSIONAL CORRELATION SPECTROSCOPY
ASHWORTH, DM
ROBINSON, JA
TURNER, DL
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (09) : 491 - 493
[10] DNA AND CHOLESTEROL-BIOSYNTHESIS IN SYNCHRONIZED EMBRYONIC RAT FIBROBLASTS .2. EFFECTS OF STEROL BIOSYNTHESIS INHIBITORS ON CELL-DIVISION
ASTRUC, M
ROUSSILLON, S
DEFAY, R
DESCOMPS, B
DEPAULET, AC
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 763 (01) : 11 - 18

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