ACCIDENTAL CHILDHOOD DEATH FROM DIPHENHYDRAMINE OVERDOSAGE

被引:38
作者
GOETZ, CM
LOPEZ, G
DEAN, BS
KRENZELOK, EP
机构
[1] Pittsburgh Poison Center, Children's Hospital of Pittsburgh, School of Pharmacy
[2] Georgia Poison Control Center, Grady Memorial Hospital
关键词
Diphenhydramine; overdose; seizures; thiopental;
D O I
10.1016/0735-6757(90)90085-E
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A 15-month-old boy presented to an emergency department with tonic clonic jerking of all extremities and dancing eye movements. A history of instant coffee ingestion was obtained at that time. However, a routine blood analysis and toxicology screen showed a diphenhydramine level of 1.0 mg% (lethal, 0.5 mg%). Generalized tonic clonic seizures continued despite conventional therapy. A continuous thiopental infusion was used to control his seizure activity. This child nerve regained consciousness and was pronounced dead 7 days postingestion. © 1990.
引用
收藏
页码:321 / 322
页数:2
相关论文
共 10 条
[1]  
Douglas, Histamine and 5-hydroxytryptamine (serotonin) and their antagonists, The Pharmacological Basis of Therapeutics, pp. 605-638, (1985)
[2]  
Litovitz, Schmitz, Matyunas, Et al., 1987 annual report of the American Association of Poison Control Centers National Data Collection System, The American Journal of Emergency Medicine, 6, pp. 479-515, (1987)
[3]  
Mofenson, Greesher, Diphenhydramine management, Poisindex, (1989)
[4]  
Ellenhorn, Barceloux, Medical Toxicology: Diagnosis and Treatment of Human Poisoning, pp. 536-541, (1988)
[5]  
Wyngaarden, Seevers, The toxic effects of antihistaminic drugs, JAMA, 145, pp. 277-282, (1951)
[6]  
Hestand, Teske, Diphenhydramine hydrochloride intoxication, J Pediatr, 90, pp. 1017-1018, (1977)
[7]  
Hausman, Weiver, Wellhouer, Et al., Lethal intoxication with diphenhydramine, Archives of Toxicology, 53, pp. 33-39, (1983)
[8]  
Koppel, Ibe, Tenczer, Clinical symptomatology of diphenhydramine: An evaluation of 136 cases from 1982 to 1985, Clin Toxicol, 25, pp. 53-70, (1987)
[9]  
Rinder, D'Amato, Rinder, Et al., Survival in complicated diphenhydramine overdose, Crit Care Med, 16, pp. 1161-1162, (1988)
[10]  
Jones, Dougherty, Cannon, Diphenhydramine-induced toxic psychosis, Am J Emerg Med, 4, pp. 369-371, (1986)