EFFECT OF TUFTSIN AND ITS RETRO-INVERSO ANALOG ON THE RELEASE OF INTERFERON (IFN-GAMMA) AND TUMOR-NECROSIS-FACTOR (TNF-ALPHA) BY HUMAN-LEUKOCYTES

被引：6

作者：

PAULESU, L

DISTEFANO, A

LUZZI, E

BOCCI, V

SILVESTRI, S

NENCIONI, L

机构：

[1] UNIV SIENA,DIPARTIMENTO BIOL MOLEC,I-53100 SIENA,ITALY

[2] SCLAVO RES CTR,SIENA,ITALY

来源：

IMMUNOLOGY LETTERS | 1992年 / 34卷 / 01期

关键词：

INTERFERON; TUMOR NECROSIS FACTOR; NATURAL TUFTSIN; RETRO-INVERSO-TUFTSIN ANALOG;

D O I：

10.1016/0165-2478(92)90020-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of this work was to demonstrate whether natural tuftsin or a retro-inverso (r.i.) analogue may induce interferon (IFN) and tumor necrosis factor (TNF) in peripheral-blood-mononuclear-cells (PBMC). For this purpose tuftsin or its analogue were added at different molar concentrations to PBMC and the supernatants were tested for IFN and TNF activity. Both cytokines were released after 12 hours incubation with r.i. tuftsin at an optimum concentration of 10(-10) M. Under the same conditions no activity was observed in the presence of natural tuftsin. In comparison to natural tuftsin the stimulatory activity of this tuftsin analogue is likely to be due to its high stability.

引用

页码：7 / 11

页数：5

共 22 条

[1] CHARACTERIZATION AND SYNTHESIS OF A MACROPHAGE INHIBITORY PEPTIDE FROM THE 2ND CONSTANT DOMAIN OF HUMAN IMMUNOGLOBULIN-G [J].