6-CHLORO-2,3-DIHYDRO-4H-1-BENZOPYRAN CARBOXYLIC-ACIDS - SYNTHESIS, OPTICAL RESOLUTION AND ABSOLUTE-CONFIGURATION

被引：27

作者：

LOIODICE, F

LONGO, A

BIANCO, P

TORTORELLA, V

机构：

[1] Dipartimento Farmaco-Chimico, Università degli Studi di Bari, 70126 Bari

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 04期

关键词：

D O I：

10.1016/0957-4166(95)00111-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

6-Chloro-2,3-dihydro-4H-1-benzopyran-2-carboxylic acid, a rigid analogue of clofibric acid, the active metabolite of the antilipidemic drug clofibrate, has been prepared together with two isomers, 6-chloro-2,3-dihydro-4H-1-benzopyran-3- and 4-carboxylic acids. The three acids have been resolved into their optical antipodes and the absolute configuration established by chemical correlation.

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页码：1001 / 1011

页数：11

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