REMARKABLY BROAD SUBSTRATE-SPECIFICITY OF A MODULAR POLYKETIDE SYNTHASE IN A CELL-FREE SYSTEM

被引：48

作者：

PIEPER, R

LUO, GL

CANE, DE

KHOSLA, C

机构：

[1] STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305

[2] BROWN UNIV,DEPT CHEM,PROVIDENCE,RI 02912

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1995年 / 117卷 / 45期

关键词：

D O I：

10.1021/ja00150a049

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：11373 / 11374

页数：2

共 30 条

[1] 6-DEOXYERYTHRONOLIDE-B SYNTHASE-2 FROM SACCHAROPOLYSPORA-ERYTHRAEA - CLONING OF THE STRUCTURAL GENE, SEQUENCE-ANALYSIS AND INFERRED DOMAIN-STRUCTURE OF THE MULTIFUNCTIONAL ENZYME [J].

BEVITT, DJ ;

CORTES, J ;

HAYDOCK, SF ;

LEADLAY, PF .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 204 (01) :39-49

[2] A MUTANT GENERATED BY EXPRESSION OF AN ENGINEERED DEBS1 PROTEIN FROM THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE (PKS) IN STREPTOMYCES-COELICOLOR PRODUCES THE TRIKETIDE AS A LACTONE, BUT THE MAJOR PRODUCT IS THE NOR-ANALOG DERIVED FROM ACETATE AS STARTER ACID [J].

BROWN, MJB ;

CORTES, J ;

CUTTER, AL ;

LEADLAY, PF ;

STAUNTON, J .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (15) :1517-1518

[3] ERYTHROMYCIN BIOSYNTHESIS - HIGHLY EFFICIENT INCORPORATION OF POLYKETIDE CHAIN ELONGATION INTERMEDIATES INTO 6-DEOXYERYTHRONOLIDE-B IN AN ENGINEERED STREPTOMYCES HOST [J].

CANE, DE ;

LUO, GG ;

KHOSLA, C ;

KAO, CM ;

KATZ, L .

JOURNAL OF ANTIBIOTICS, 1995, 48 (07) :647-651

[4] UNIFIED STEREOCHEMICAL MODEL OF POLYETHER ANTIBIOTIC-STRUCTURE AND BIOGENESIS [J].

CANE, DE ;

CELMER, WD ;

WESTLEY, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (11) :3594-3600

[5]

CELMER W D, 1971, Pure and Applied Chemistry, V28, P413, DOI 10.1351/pac197128040413

[6] MACROLIDE STEREOCHEMISTRY .3. A CONFIGURATIONAL MODEL FOR MACROLIDE ANTIBIOTICS [J].

CELMER, WD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (08) :1801-&

[7] AN UNUSUALLY LARGE MULTIFUNCTIONAL POLYPEPTIDE IN THE ERYTHROMYCIN-PRODUCING POLYKETIDE SYNTHASE OF SACCHAROPOLYSPORA-ERYTHRAEA [J].

CORTES, J ;

HAYDOCK, SF ;

ROBERTS, GA ;

BEVITT, DJ ;

LEADLAY, PF .

NATURE, 1990, 348 (6297) :176-178

[8] BIOSYNTHESIS OF 6-METHYLSALICYLIC ACID [J].

DIMROTH, P ;

WALTER, H ;

LYNEN, F .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1970, 13 (01) :98-&

[9]

DIMROTH P, 1970, EUR J BIOCHEM, P98

[10] ORGANIZATION OF THE ENZYMATIC DOMAINS IN THE MULTIFUNCTIONAL POLYKETIDE SYNTHASE INVOLVED IN ERYTHROMYCIN FORMATION IN SACCHAROPOLYSPORA-ERYTHRAEA [J].

DONADIO, S ;

KATZ, L .

GENE, 1992, 111 (01) :51-60

← 1 2 3 →