METHOTREXATE INFUSION AND FOLINIC ACID IN THE PRIMARY THERAPY OF NONMETASTATIC GESTATIONAL TROPHOBLASTIC TUMORS

被引：39

作者：

BERKOWITZ, RS ^{[1
]}

GOLDSTEIN, DP ^{[1
]}

BERNSTEIN, MR ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

GYNECOLOGIC ONCOLOGY | 1990年 / 36卷 / 01期

关键词：

D O I：

10.1016/0090-8258(90)90108-W

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thirty-two patients with nonmetastatic gestational trophoblastic tumors were treated with methotrexate infusion and folinic acid and the results of this therapy were compared to our prior experience with the 8-day methotrexate-folinic acid regimen. Complete remission was achieved in 22 of 32 (68.7%) patients treated with methotrexate infusion and 147 of 163 (90.2%) patients treated with the 8-day regimen (P < 0.01). One course of chemotherapy induced complete remission in 19 (86.3%) patients treated with methotrexate infusion and 121 (82.2%) patients treated with the 8-day regimen. All 10 patients resistant to methotrexate infusion later achieved remission with other chemotherapy. Following methotrexate infusion, no patient developed myelosuppression, hepatotoxicity, or alopecia. Efforts should continue to identify new chemotherapeutic protocols that maximize remission rates and minimize toxicity and hospitalization. © 1990.

引用

页码：56 / 59

页数：4

共 23 条

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[2] TREATMENT OF NONMETASTATIC GESTATIONAL TROPHOBLASTIC DISEASE WITH ORAL METHOTREXATE [J].