AGING DOES NOT ALTER MUSCARINIC RECEPTOR-MEDIATED INHIBITION OF CYCLIC-AMP FORMATION IN THE STRIATUM AND HIPPOCAMPUS

被引：10

作者：

ABDALLAH, EAM ^{[1
]}

POU, WS ^{[1
]}

ELFAKAHANY, EE ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH PHARM,DEPT PHARMACOL & TOXICOL,20 N PINE ST,BALTIMORE,MD 21201

来源：

BRAIN RESEARCH | 1990年 / 534卷 / 1-2期

关键词：

Aging; Cyclic adenosine monophosphate; Fischer; 344; rat; Hippocampus; Muscarinic; Striatum;

D O I：

10.1016/0006-8993(90)90133-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of aging on the inhibition of forskolin-stimulated cyclic AMP formation by muscarinic receptors were investigated. There were no detectable changes in the magnitude of maximal inhibition by carbamylcholine or the potency of the agonist in inducing this response in either the striatum or hippocampus obtained from young or old Fisher 344 rats. © 1990.

引用

页码：234 / 236

页数：3

共 22 条

[1] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION
BARTUS, RT
DEAN, RL
BEER, B
LIPPA, AS
[J]. SCIENCE, 1982, 217 (4558) : 408 - 417
[2] AGING AND BRAIN CHOLINERGIC MUSCARINIC RECEPTOR SUBTYPES - AN AUTORADIOGRAPHIC STUDY IN THE RAT
BIEGON, A
HANAU, M
GREENBERGER, V
SEGAL, M
[J]. NEUROBIOLOGY OF AGING, 1989, 10 (04) : 305 - 310
[3] BLAKE MJ, IN PRESS NEUROBIOL A
[4] INVIVO AND INVITRO STUDIES ON THE REGULATION OF CHOLINERGIC NEUROTRANSMISSION IN STRIATUM, HIPPOCAMPUS AND CORTEX OF AGED RATS
CONSOLO, S
WANG, JX
FIORENTINI, F
VEZZANI, A
LADINSKY, H
[J]. BRAIN RESEARCH, 1986, 374 (02) : 212 - 218
[5] THE EFFECTS OF AGING ON HIPPOCAMPAL AND CORTICAL PROJECTIONS OF THE FOREBRAIN CHOLINERGIC SYSTEM
DECKER, MW
[J]. BRAIN RESEARCH REVIEWS, 1987, 12 (04) : 423 - 438
[6] EFFECTS OF ETHANOL INVIVO AND INVITRO ON STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN RAT CORTEX AND CEREBELLUM
GONZALES, RA
CREWS, FT
[J]. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1988, 12 (01) : 94 - 98
[7] Haigler HJ, 1985, BRAIN RES, V362, P157
[8] PERTUSSIS TOXIN SEPARATES 2 MUSCARINIC RECEPTOR-EFFECTOR MECHANISMS IN THE STRIATUM
KELLY, E
ROONEY, TA
NAHORSKI, SR
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 119 (1-2) : 129 - 130
[9] THE ACTIVATION OF PHOSPHATIDYLINOSITOL TURNOVER IS NOT DIRECTLY INVOLVED IN THE MODULATION OF NEUROTRANSMITTER RELEASE MEDIATED BY PRESYNAPTIC MUSCARINIC RECEPTORS
MARCHI, M
FONTANA, G
PAUDICE, P
RAITERI, M
[J]. NEUROCHEMICAL RESEARCH, 1988, 13 (09) : 903 - 907
[10] MCKINNEY M, 1989, J PHARMACOL EXP THER, V250, P565

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