MATERNAL ANTIBODIES TO GP120 V3 SEQUENCE DO NOT CORRELATE WITH PROTECTION AGAINST VERTICAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS

被引:54
作者
ROBERTSON, CA
MOK, JYQ
FROEBEL, KS
SIMMONDS, P
BURNS, SM
MARSDEN, HS
GRAHAM, S
机构
[1] UNIV GLASGOW,MRC,VIROL UNIT,CHURCH ST,GLASGOW G11 5JR,SCOTLAND
[2] CITY HOSP EDINBURGH,REG INFECT DIS UNIT,EDINBURGH EH10 5SB,MIDLOTHIAN,SCOTLAND
[3] UNIV EDINBURGH,ROYAL EDINBURGH INFIRM,DEPT CHEM,EDINBURGH EH10 5HF,MIDLOTHIAN,SCOTLAND
[4] UNIV EDINBURGH,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND
关键词
D O I
10.1093/infdis/166.4.704
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A retrospective study of sera from mothers infected with human immunodeficiency virus (HIV-1) was undertaken to investigate whether the titers or affinities of antibodies against the third hypervariable region (V3 loop) of gp120 correlated with transmission of the virus from mother to child. The cohort comprised 7 mothers who transmitted HIV-1 to their children and 20 who did not. Sera were screened for reactivity against two synthetic peptides, one encompassing the entire V3 loop of gp120 (amino acids 297-330) and the other containing an immunodominant epitope from gp41 (amino acids 596-614). Doubling dilutions of sera were tested to obtain antibody titers against both peptides: Anti-gp41 titers were used to normalize the anti-V3 titers. Maternal sera were also screened for the presence of high-affinity antibodies against the V3 peptide. No differences were observed in either titers or affinities of maternal antibodies to the V3 sequence from transmitters and nontransmitters.
引用
收藏
页码:704 / 709
页数:6
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