DIFFERENTIAL INTRACELLULAR COMPARTMENTALIZATION OF PHOSPHOTYROSINE PHOSPHATASES IN A GLIAL-CELL LINE - TC-PTP VERSUS PTP-1B

被引：17

作者：

FAURE, R

POSNER, BI

机构：

[1] MCGILL UNIV, DEPT MED, MONTREAL H3A 2B2, QUEBEC, CANADA

[2] ROYAL VICTORIA HOSP, MONTREAL H3A 2B2, PQ, CANADA

来源：

GLIA | 1993年 / 9卷 / 04期

关键词：

PROTEIN TYROSINE PHOSPHATASES; LOCALIZATION; IMMUNOFLUORESCENCE; C6; GLIOMA;

D O I：

10.1002/glia.440090409

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracellular levels of protein-phosphotyrosine are regulated by the protein-tyrosine phosphatase (PTP) family. Cellular compartmentalization may play an important role in modulating the function of these enzymes. The recent demonstration that PTP-1B is localized to the endoplasmic reticulum (Frangioni et al: Cell 68:545, 1992) is consistent with this proposition. In this study we have examined the intracellular distribution of TC-PTP in a glial cell line (C6). Using indirect immunofluorescence we have shown that this enzyme is distributed differently from PTP-1B and is mainly concentrated in the perinuclear region of these cells. (C) 1993 Wiley-Liss, Inc.

引用

页码：311 / 314

页数：4

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