MUPIROCIN RESISTANCE AMONG CONSECUTIVE ISOLATES OF OXACILLIN-RESISTANT AND BORDERLINE OXACILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS AT A UNIVERSITY HOSPITAL

被引：37

作者：

LAYTON, MC

PATTERSON, JE

机构：

[1] YALE UNIV,SCH MED,DEPT MED,INFECT DIS SECT,NEW HAVEN,CT 06520

[2] YALE UNIV,SCH MED,DEPT LAB MED,NEW HAVEN,CT 06520

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 07期

关键词：

D O I：

10.1128/AAC.38.7.1664

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mupirocin resistance was determined in consecutive oxacillin-resistant and borderline oxacillin-resistant Staphylococcus aureus clinical isolates collected over 14 months at a university hospital during 1991 and 1992. Twenty of 86 (23%) oxacillin-resistant and borderline oxacillin-resistant S. aureus isolates were mupirocin resistant; 80% were high-level resistant. Prior mupirocin use was a significant risk factor (relative risk, 6.08; 95% confidence interval, 3.7 to 9.99). Seven of 20 resistant isolates were distinct strains, as determined by pulsed-field gel electrophoresis typing. Two instances of clonal dissemination of a single strain occurred, but several other distinct mupirocin-resistant strains were documented. Mupirocin resistance was unexpectedly common among these isolates.

引用

页码：1664 / 1667

页数：4

共 38 条

[1] DETECTION OF METHICILLIN RESISTANCE IN STAPHYLOCOCCI BY USING A DNA PROBE [J].