POTENTIATION OF ANTITUMOR EFFECT OF BLEOMYCIN BY LOCAL ELECTRIC PULSES IN MOUSE BLADDER-TUMOR

被引：30

作者：

YAMAGUCHI, O

IRISAWA, C

BABA, K

OGIHARA, M

YOKOTA, T

SHIRAIWA, Y

机构：

[1] Department of Urology, Fukushima Medical College

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1994年 / 172卷 / 03期

关键词：

ELECTROCHEMOTHERAPY; ELECTROPORATION; BLEOMYCIN; MOUSE BLADDER TUMOR;

D O I：

10.1620/tjem.172.291

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

C3H mice bearing subcutaneously transplanted mouse bladder carcinouma (MBT-2) were treated with intramuscular injection of bleomycin followed by local delivery of electric pulses at the tumor site. The tumors markedly reduced and even disappeared for several days after this treatment. Neither electric pulses nor bleomycin administration alone showed a significant inhibitory effect on the tumor growth. Thus, it is demonstrated that in mouse bladder tumor the antitumor effect of bleomycin can be considerably potentiated by local electric pulses.

引用

页码：291 / 293

页数：3

共 5 条

[1] ELECTROCHEMOTHERAPY OF SPONTANEOUS MAMMARY-TUMORS IN MICE [J].