PYRROLOPYRIMIDINE NUCLEOSIDES .13. SYNTHESIS AND CHEMICAL REACTIVITY OF CERTAIN SELENOPYRROLO[2,3-D]PYRIMIDINE NUCLEOSIDES

被引：6

作者：

MILNE, GH

TOWNSEND, LB

机构：

[1] UNIV UTAH, DEPT BIOPHARM SCI, DIV MED CHEM, SALT LAKE CITY, UT 84112 USA

[2] UNIV UTAH, DEPT CHEM, SALT LAKE CITY, UT 84112 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1976年 / 13卷 / 04期

关键词：

D O I：

10.1002/jhet.5570130411

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5-Cyano-7-(.beta.-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidin-4-selone was prepared via a reaction of the appropriate 4-chloro compound with sodium hydrogen selenide. Alkylation under basic conditions has provided certain 4-substitutedseleno-5-cyano-7-(.beta.-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidines as potential drugs. 5-Cyano-4-methylseleno-7-(.beta.-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine was allowed to react with hydroxylamine and hydrazine. The products obtained and reaction course were compared to those obtained from identical reactions using the corresponding S analogue.

引用

页码：745 / 748

页数：4

共 8 条

[1] PYRROLOPYRIMIDINE NUCLEOSIDES .10. SYNTHESIS OF CERTAIN 4,5-DISUBSTITUTED 7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINES RELATED TO TOYOCAMYCIN AND SANGIVAMYCIN [J].