APOPTOSIS IS A COMMON HISTOPATHOLOGICAL FINDING IN MYELODYSPLASIA - THE CORRELATE OF INEFFECTIVE HEMATOPOIESIS

被引：83

作者：

CLARK, DM ^{[1
]}

LAMPERT, IA ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOPATHOL,DU CANE RD,LONDON W12 ONN,ENGLAND

来源：

LEUKEMIA & LYMPHOMA | 1990年 / 2卷 / 06期

关键词：

Apoptosis; Bone marrow biopsy; Myelodysplasia;

D O I：

10.3109/10428199009069295

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Twenty-three bone marrow biopsies from patients with myelodysplastic syndromes (MDS) with typical histological features were studied, and evidence of apoptosis of erythroid and immature myeloid precursors was seen by light microscopy in each case. This was quantified and found to be significantly greater than that seen in ten normal bone marrow biopsies (p < 0.01). There was no difference in the degree of apoptosis seen in the various sub-groups of MDS proposed by the French-American-British (FAB) co-operative group. These results show apoptosis of haemopoietic precursors to be a characteristic histological finding in MDS, representing intramedullary death of these cells, a factor that may play a role in the pathogenesis of the cytopenias seen in this condition. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：415 / 418

页数：4

共 12 条

[1]

Koeffler H.P., Golde D.W., Human preleukaemia, Ann. Int. Med, 93, pp. 347-353, (1980)

[2]

Bennett J.M., Catovsky D., Daniel M.T., Flandrin G., Galton D.A.G., Gralnick H.R., Sultan C., Proposals for the classification of myelodysplastic syndromes, Br. J. Haematol, 51, pp. 189-199, (1982)

[3]

Tricot G., De Wolf-Peters C., Hendrickx B., Verwilghen R.I., Bone marrow biopsy in myelodysplastic syndromes. I. Histological findings in myelodysplastic syndromes and comparison with bone marrow smears, Br. J. Haematol, 57, pp. 423-430, (1984)

[4]

Frish B., Bartl R., Bone marrow histology in myelodysplastic syndromes, Scand. J. Haematol, 35, pp. 21-37, (1986)

[5]

Delacretaz F., Schmidt P.M., Piguet D., Bachmann F., Costa J., Histopathology of myelodysplastic syndromes. The FAB classification proposals applied to Bone marrow biopsy, Am. J. Clin. Path, 87, pp. 180-186, (1987)

[6]

Tricot G., De Wolf-Peters C., Hendrickx B., Verwilghen R.I., Bone marrow biopsy in myelodysplastic syndromes. II. Prognostic value of abnormal localization of immature precursors in MDS, Br. J. Haematol, 58, pp. 217-225, (1984)

[7]

Wyllie A.H., Kerr J.F.R., Currie A.R., Cell death: The significance of apoptosis, Int. Rev. Cytology, 68, pp. 251-299, (1980)

[8]

Wyllie A.H., Glucocorticoid induced thymocyte apoptosis is associated with endogenous endonuclease activity, Nature, 284, pp. 555-556, (1980)

[9]

Baxter G.D., Collins R.J., Harmon B.V., Kumar S., Prentice R.L., Smith P.J., Lavin M.F., Cell death by apoptosis in acute leukaemia, J. Pathol, 158, pp. 123-129, (1989)

[10]

Wyllie A.H., Morris R.G., Smith A.L., Dunlop D., Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis, J. Pathol, 142, pp. 67-77, (1984)

← 1 2 →