POSITIVE DARWINIAN EVOLUTION IN HUMAN INFLUENZA-A VIRUSES

被引：273

作者：

FITCH, WM ^{[1
]}

LEITER, JME ^{[1
]}

LI, XQ ^{[1
]}

PALESE, P ^{[1
]}

机构：

[1] CUNY MT SINAI SCH MED,DEPT MICROBIOL,NEW YORK,NY 10029

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 10期

关键词：

POSITIVE SELECTION; HEMAGGLUTININS; NONSTRUCTURAL PROTEIN; RATES OF EVOLUTION; IMMUNE SURVEILLANCE;

D O I：

10.1073/pnas.88.10.4270

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We earlier suggested that type A human influenza virus genes undergo positive Darwinian selection through immune surveillance. This requires more favorable amino acid replacements fixed in antigenic sites among the surviving lineages than among the extinct lineages. We now show that viral hemagglutinins fix proportionately more amino acid replacements in antigenic sites in the trunk of the evolutionary tree (survivors) than in the branches (nonsurvivors), demonstrating that type A human influenza virus is undergoing positive Darwinian evolution. The hemagglutinin gene is evolving 3 times faster than the nonstructural gene and the average age of the sampled nonsurvivors is only 1.6 years, so that extinction is not only common but rapid.

引用

页码：4270 / 4274

页数：5

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