TIME-DEPENDENCY FOR THE BIMODAL EFFECT OF MELATONIN ON CALCIUM-UPTAKE IN RAT HYPOTHALAMUS

被引：9

作者：

ROSENSTEIN, RE ^{[1
]}

GOLOMBEK, DA ^{[1
]}

KANTEREWICZ, BI ^{[1
]}

CARDINALI, DP ^{[1
]}

机构：

[1] UNIV BUENOS AIRES,FAC MED,DEPT FISIOL,CC 243,RA-1425 BUENOS AIRES,ARGENTINA

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1991年 / 85卷 / 03期

关键词：

MELATONIN; PINEAL GLAND; CALCIUM UPTAKE; HYPOTHALAMUS; SYNAPTOSOMES;

D O I：

10.1007/BF01244949

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The activity of 0.01-1-mu-M of melatonin on depolarization-induced Ca-45(2+) influx by hypothalamic synaptosomes of rats killed at late evening (2000 h) depended on melatonin preincubation time, exhibiting an early (10 min) stimulation of uptake and an inhibition after 30 min of incubation. Both stimulatory and inhibitory effects were maximal at 2000 h and tended to a minimum at 2400 h, exhibiting intermediate values at 400 h. At 1000 h, only inhibitory effects of melatonin (1-mu-M) on Ca2+ uptake were found.

引用

页码：243 / 247

页数：5

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