HYDROXYPROPYLMETHYLCELLULOSE MATRIX TABLETS CONTAINING PROPRANOLOL HYDROCHLORIDE AND SODIUM DODECYL-SULFATE

被引：21

作者：

FORD, JL ^{[1
]}

MITCHELL, K ^{[1
]}

SAWH, D ^{[1
]}

RAMDOUR, S ^{[1
]}

ARMSTRONG, DJ ^{[1
]}

ELLIOTT, PNC ^{[1
]}

ROSTRON, C ^{[1
]}

HOGAN, JE ^{[1
]}

机构：

[1] COLORCON LTD,ORPINGTON BR5 3QY,KENT,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 71卷 / 03期

关键词：

HYDROXYPROPYLMETHYLCELLULOSE; SODIUM DODECYL SULFATE; CETRIMIDE; PROPRANOLOL HYDROCHLORIDE; MATRIX TABLET; DISSOLUTION RATE;

D O I：

10.1016/0378-5173(91)90392-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anionic surface-active agent, sodium dodecyl sulphate, when included into matrix tablets containing hydroxypropylmethylcellulose (HPMC K15M) retarded the release rate of propranolol hydrochloride by the formation of propranolol dodecyl sulphate. The root-time dissolution rates from these tablets were proportional to the unreacted propranolol hydrochloride. Propranolol dodecyl sulphate formed lyotropic liquid crystals on contact with water. On heating, this hydration was lost at 36-degrees-C. The estimated solubility product of this compound was less than 4 x 10(-8) M2. The ternary phase diagram of sodium dodecyl sulphate-propranolol hydrochloride-water was established and confirmed the approximate 1:1 w/w nature of the precipitate. Similar interactions did not occur between propranolol hydrochloride and cetrimide which, when included in HPMC matrix tablets, marginally increased the dissolution rate of propranolol hydrochloride.

引用

页码：213 / 221

页数：9

共 11 条

[1]

ALDERMAN D A, 1984, International Journal of Pharmaceutical Technology and Product Manufacture, V5, P1

[2] THE EFFECT OF ANIONIC SURFACTANTS ON THE RELEASE OF CHLORPHENIRAMINE FROM A POLYMER MATRIX TABLET [J].