LACIDIPINE - A DIHYDROPYRIDINE CALCIUM-ANTAGONIST WITH ANTIOXIDANT ACTIVITY

被引：107

作者：

VANAMSTERDAM, FTM

ROVERI, A

MAIORINO, M

RATTI, E

URSINI, F

机构：

[1] UNIV PADUA,DEPT BIOL CHEM,V TRIESTE 75,I-35121 PADUA,ITALY

[2] GLAXO RES LABS,VERONA,ITALY

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1992年 / 12卷 / 03期

关键词：

HYPERTENSION; CALCIUM BLOCKER; ANTIOXIDANTS; LIPID PEROXIDATION; LACIDIPINE; FREE RADICALS;

D O I：

10.1016/0891-5849(92)90025-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lacidipine, a new, long-acting antihypertensive dihydropyridine calcium antagonist was tested for potential antioxidant effect in a series of tests that consider specific radical species. A direct quenching of several radical species could be measured. Moreover, in biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E.

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页码：183 / 187

页数：5

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