RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR FOLLOWED BY IMMUNOSUPPRESSIVE THERAPY FOR APLASTIC-ANEMIA

被引：11

作者：

DONEY, K ^{[1
]}

STORB, R ^{[1
]}

APPELBAUM, FR ^{[1
]}

BUCKNER, CD ^{[1
]}

SANDERS, J ^{[1
]}

SINGER, J ^{[1
]}

HANSEN, JA ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT MED,SEATTLE,WA 98195

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 85卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1993.tb08665.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Seventeen patients with aplastic anaemia were treated with recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) for 14 d. Nonresponding patients were then treated with anti-human thymocyte globulin (ATG), methylprednisolone and oxymetholone. Side-effects of rhGM-CSF included fever, nausea and vomiting, diarrhoea, bone pain, headache and chills. Two patients had sustained trilineage haemopoietic recovery after receiving only rhGM-CSF. Of 11 patients who received immunosuppressive therapy, there was one complete response, two partial responses. one minimal response, and seven nonresponses. Actuarial survival at 2 years is 64%. Early administration of rhGM-CSF had no apparent effect on subsequent response to immunosuppressive therapy.

引用

页码：182 / 184

页数：3

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