NONCYTOTOXIC, IL-4, IL-5, IL-10 PRODUCING CD8+ T-CELLS - THEIR ACTIVATION AND EFFECTOR FUNCTIONS

被引：91

作者：

LEGROS, G

ERARD, F

机构：

[1] Ciba, Basel

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 03期

关键词：

D O I：

10.1016/0952-7915(94)90127-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD8(+) T cells activated in the presence of IL-4 can develop into distinct, non-cytotoxic CD8(-) and cytotoxic CD8(+) subsets that produce IL-4, IL-5, IL-10 but do not produce IFN-gamma. These 'Th2 like' CD8(+) cells may enhance Th2 responses, help B cells or suppress Th1 immune responses. Importantly, the switch from the cytotoxic, IFN-gamma producing CD8(+) T-cell phenotype could compromise the host response to infectious agents such as HIV.

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页码：453 / 457

页数：5

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