ARTERIAL-WALL CHANGES IN TYPE-2 DIABETIC SUBJECTS

被引：41

作者：

GEROULAKOS, G

RAMASWAMI, G

VELLER, MG

FISHER, GM

RENTON, S

NICOLAIDES, A

WALDRON, HA

DIAMOND, J

ELKELES, RS

机构：

[1] Irvine Laboratory, Academic Surgical Unit, London

[2] Department of Occupational Health, London

[3] Academic Department of Public Health, London

[4] Unit of Metabolic Medicine, St Mary's Hospital Medical School, London

来源：

DIABETIC MEDICINE | 1994年 / 11卷 / 07期

关键词：

TYPE-2; DIABETES; CAROTID INTIMA-MEDIA THICKNESS; ATHEROSCLEROSIS;

D O I：

10.1111/j.1464-5491.1994.tb00334.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Arterial ultrasonic appearances using high resolution ultrasound were studied in 97 subjects with Type 2 diabetes and age- and sex-matched controls. The intima-media thickness of both common carotid arteries was measured 2 cm proximal to the bifurcation and the presence-or absence of plaque on both common and femoral bifurcations was recorded. The mean intima-media thickness in subjects with diabetes was 0.82 +/- 0.22 mm while in the controls 0.66 +/- 0.13 mm (p<0.001). Multiple regression in diabetic subjects only showed no correlation between 'age, sex, body mass index, smoking, duration of diabetes, systolic or diastolic blood pressure, cholesterol, HDL, LDL, triglycerides, HbA, and the common carotid artery intima-media thickness. Type 2 diabetes is associated with increased intima-media thickness which has been found to be a marker of cardiovascular events in the general population.

引用

页码：692 / 695

页数：4

共 17 条

[1]

Panzram G., Mortality and survival in type 2 (non insulin dependent) diabetes mellitus, Diabetologia, 30, pp. 123-131, (1987)

[2]

Uusitupa MIJ, Niskanen LK, Siitonen O., Voutilainen E., Pyorala KI, 5‐year incidence of atherosclerotic vascular disease in relation to general risk factors, insulin level and abnormalities in lipoprotein composition in non‐insulin dependent diabetic and non‐diabetic subjects, Circulation, 82, pp. 27-36, (1990)

[3]

Kannel WB, McGee DL, Diabetes and cardiovascular disease. The Framing ham Study, J Am Med Assoc, 241, pp. 2035-2038, (1979)

[4]

Stamler J., Wentworth D., Neaton J., Schoenberger JA, Diabetes and risk of coronary, cardiovascular and all causes mortality: findings for 356,000 men screened by the Multiple Risk Factor Intervention Trial (MRFIT), Circulation, 70, (1984)

[5]

Woolf N., Diabetes and atherosclerosis, Acta Diab Lat, 8, pp. 14-42, (1971)

[6]

Poli A., Tremoli E., Colombo A., Sirtori M., Pignoli P., Paoletti R., Ultrasonographic measurement of the common carotid artery wall thickness in hypercholesterolaemic patients. A new model for the quantitation and follow‐up of preclinical atherosclerosis in living human subjects, Artherosclerosis, 70, pp. 253-261, (1988)

[7]

Zweibel WJ, High resolution B‐mode and duplex carotid sonography, Introduction to Vascular Sonography., pp. 103-109, (1982)

[8]

James EM, Earnest IV, Forbes DF, High resolution dynamic ultrasound imaging of the carotid bifurcation: a prospective evaluation, Radiology, 144, (1982)

[9]

Pignoli P., Tremoli E., Poli A., Oreste P., Paoletti R., Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging, Circulation, 6, pp. 1399-1406, (1986)

[10]

Salonen R., Salonen JT, Determinants of carotid intima‐media thickness: a population based ultrasonography study in Eastern Finnish men, J Int Med, 229, pp. 225-231, (1991)

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