CYCLINS, CDKS AND CANCER

被引：170

作者：

PINES, J

机构：

[1] Wellcome/CRC Institute, Cambridge, CB2 1QR, Tennis Court Road

来源：

SEMINARS IN CANCER BIOLOGY | 1995年 / 6卷 / 02期

基金：

英国惠康基金;

关键词：

CANCER; CELL CYCLE; CYCLINS; CDKS; KINASES; ONCOGENESIS;

D O I：

10.1006/scbi.1995.0009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes. In this review I will attempt to show how perturbations in the known cell cycle regulators may play a part in the process of oncogenesis.

引用

收藏

页码：63 / 72

页数：10

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