CYCLINS, CDKS AND CANCER

被引:170
作者
PINES, J
机构
[1] Wellcome/CRC Institute, Cambridge, CB2 1QR, Tennis Court Road
基金
英国惠康基金;
关键词
CANCER; CELL CYCLE; CYCLINS; CDKS; KINASES; ONCOGENESIS;
D O I
10.1006/scbi.1995.0009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes. In this review I will attempt to show how perturbations in the known cell cycle regulators may play a part in the process of oncogenesis.
引用
收藏
页码:63 / 72
页数:10
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