EVOLUTION OF THE CRYPTIC FMR1 CGG REPEAT

被引:40
作者
EICHLER, EE
KUNST, CB
LUGENBEEL, KA
RYDER, OA
DAVISON, D
WARREN, ST
NELSON, DL
机构
[1] BAYLOR COLL MED,CTR HUMAN GENOME,DEPT HUMAN & MOLEC GENET,HOUSTON,TX 77030
[2] EMORY UNIV,SCH MED,HOWARD HUGHES MED INST,DEPT BIOCHEM,ATLANTA,GA 30322
[3] EMORY UNIV,SCH MED,DEPT PEDIAT,ATLANTA,GA 30322
[4] ZOOL SOC SAN DIEGO,CTR REPROD ENDANGERED SPECIES,SAN DIEGO,CA 92112
[5] UNIV HOUSTON,DEPT BIOCHEM & BIOPHYS SCI & COMP SCI,HOUSTON,TX 77024
关键词
D O I
10.1038/ng1195-301
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We have sequenced the 5' untranslated region of the orthologous FMR1 gene from 44 species of mammals. The CGG repeat is present in each species, suggesting conservation of the repeat over 150 million years of mammalian radiation. Most mammals possess small contiguous repeats (mean number of repeats = 8.0 +/- 0.8), but, in primates, the repeats are larger (mean= 20.0 +/- 2.3) and more highly interrupted. Parsimony analysis predicts that enlargement of the FMR1 CGG repeat beyond 20 triplets has occurred in three different primate lineages. In man and gorilla, AGG interruptions occur with higher-order periodicity, suggesting that historical enlargement has involved incremental and vectorial addition of larger arrays demarcated by an interruption. Our data suggest that replication slippage and unequal crossing over have been operative during the evolution of this repeat.
引用
收藏
页码:301 / 308
页数:8
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