REGIONAL DISTRIBUTION OF LESIONS IN THE CENTRAL-NERVOUS-SYSTEM OF CATS INFECTED WITH FELINE IMMUNODEFICIENCY VIRUS

被引:26
作者
ABRAMO, F
BO, S
CANESE, MG
POLI, A
机构
[1] UNIV PISA,DEPT ANIM PATHOL,I-56100 PISA,ITALY
[2] UNIV TURIN,DEPT ANIM PATHOL,TURIN,ITALY
关键词
D O I
10.1089/aid.1995.11.1247
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neuropathological examination of the central nervous system of 13 naturally and 13 experimentally feline immunodeficiency virus (FIV)-infected cats revealed diffuse gliosis of gray and white matter and vacuolar myelinopathy in a large proportion of infected animals, sometimes associated with lymphocytic meningitis. Multinucleated giant cell formation, the hallmark of multifocal giant cell encephalitis in HN infection, was never observed. Morphometric analysis confirmed a marked increase of GFAP reactivity in infected cats. Gliosis was mainly present in cortical structures of frontal, parietal, and occipital lobes. Only one naturally infected animal evidenced clinical symptoms of neurological damage. This study confirms that FIV provides an interesting model for studying HIV-induced cortical and subcortical brain pathology believed to be the cause of the neurological manifestations frequently observed in AIDS patients.
引用
收藏
页码:1247 / 1253
页数:7
相关论文
共 27 条
[1]   HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION OF THE BRAIN [J].
ATWOOD, WJ ;
BERGER, JR ;
KADERMAN, R ;
TORNATORE, CS ;
MAJOR, EO .
CLINICAL MICROBIOLOGY REVIEWS, 1993, 6 (04) :339-366
[2]   FELINE IMMUNODEFICIENCY VIRUS - AN INTERESTING MODEL FOR AIDS STUDIES AND AN IMPORTANT CAT PATHOGEN [J].
BENDINELLI, M ;
PISTELLO, M ;
LOMBARDI, S ;
POLI, A ;
GARZELLI, C ;
MATTEUCCI, D ;
CECCHERININELLI, L ;
MALVALDI, G ;
TOZZINI, F .
CLINICAL MICROBIOLOGY REVIEWS, 1995, 8 (01) :87-112
[3]  
BUDKA H, 1991, ACTA PATHOL JAPON, V41, P182
[4]   BRAIN PATHOLOGY INDUCED BY INFECTION WITH THE HUMAN IMMUNODEFICIENCY VIRUS (HIV) - A HISTOLOGICAL, IMMUNOCYTOCHEMICAL, AND ELECTRON MICROSCOPICAL STUDY OF 100 AUTOPSY CASES [J].
BUDKA, H ;
COSTANZI, G ;
CRISTINA, S ;
LECHI, A ;
PARRAVICINI, C ;
TRABATTONI, R ;
VAGO, L .
ACTA NEUROPATHOLOGICA, 1987, 75 (02) :185-198
[5]  
DEGIROLAMI U, 1990, ARCH PATHOL LAB MED, V114, P643
[6]   SUBACUTE ENCEPHALOMYELITIS OF AIDS AND ITS RELATION TO HTLV-III INFECTION [J].
DELAMONTE, SM ;
HO, DD ;
SCHOOLEY, RT ;
RICHARDSON, EP ;
HIRSCH, MS .
NEUROLOGY, 1987, 37 (04) :562-569
[7]  
DOW SW, 1990, J ACQ IMMUN DEF SYND, V3, P658
[8]  
DOW SW, 1992, VET MED-US, V87, P1181
[9]   FELINE IMMUNODEFICIENCY VIRUS NEUROTROPISM - EVIDENCE THAT ASTROCYTES AND MICROGLIA ARE THE PRIMARY TARGET-CELLS [J].
DOW, SW ;
DREITZ, MJ ;
HOOVER, EA .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1992, 35 (1-2) :23-35
[10]   CLINICAL-NEUROPATHOLOGIC CORRELATION IN HIV-ASSOCIATED DEMENTIA [J].
GLASS, JD ;
WESSELINGH, SL ;
SELNES, OA ;
MCARTHUR, JC .
NEUROLOGY, 1993, 43 (11) :2230-2237