THE ALTERNATIVE SPLICING PATTERN OF THE TENASCIN-C PRE-MESSENGER-RNA IS CONTROLLED BY THE EXTRACELLULAR PH

被引：71

作者：

BORSI, L ^{[1
]}

BALZA, E ^{[1
]}

GAGGERO, B ^{[1
]}

ALLEMANNI, G ^{[1
]}

ZARDI, L ^{[1
]}

机构：

[1] IST NAZL RIC CANC,CELL BIOL LAB,I-16132 GENOA,ITALY

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 11期

关键词：

D O I：

10.1074/jbc.270.11.6243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing of primary transcripts is an ubiquitous and reversible mechanism for the generation of multiple protein isoforms from single genes, Here we report that in cultured normal human fibroblasts, small pH variations of the culture medium (from 7.2 to 6.9) strikingly modify the alternative splicing pattern of the tenascin-C primary transcript. Since such extracellular pH variations occur in many normal and pathological conditions, microenvironmental pH may be an important element for the regulation of RNA alternative splicing in vivo.

引用

页码：6243 / 6245

页数：3

共 25 条

[1]

AUSTIN C, 1993, J PHYSIOL-LONDON, V466, P1

[2] CELL-CYCLE DEPENDENT ALTERNATIVE SPLICING OF THE TENASCIN PRIMARY TRANSCRIPT [J].