METHOTREXATE ANALOGS .14. SYNTHESIS OF NEW GAMMA-SUBSTITUTED DERIVATIVES AS DIHYDROFOLATE-REDUCTASE INHIBITORS AND POTENTIAL ANTICANCER AGENTS

被引：96

作者：

ROSOWSKY, A

FORSCH, R

UREN, J

WICK, M

机构：

[1] HARVARD UNIV,SCH MED,DEPT DERMATOL,BOSTON,MA 02115

[2] HARVARD UNIV,SCH MED,DEPT PHARMACOL,BOSTON,MA 02115

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1981年 / 24卷 / 12期

关键词：

D O I：

10.1021/jm00144a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1450 / 1455

页数：6

共 30 条

[1]

ARONS E, 1975, CANCER RES, V35, P2033

[2]

Baker BR, 1967, DESIGN ACTIVE SITE D

[3] POLYGAMMAGLUTAMYL METABOLITES OF METHOTREXATE [J].

BAUGH, CM ;

KRUMDIECK, CL ;

NAIR, MG .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 52 (01) :27-34

[4] METHOTREXATE ANALOGS .3. SYNTHESIS AND BIOLOGICAL PROPERTIES OF SOME SIDE-CHAIN ALTERED ANALOGS [J].

CHAYKOVSKY, M ;

ROSOWSKY, A ;

PAPATHANASOPOULOS, N ;

CHEN, KKN ;

MODEST, EJ ;

KISLIUK, RL ;

GAUMONT, Y .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (11) :1212-1216

[5] METHOTREXATE ANALOGS .6. REPLACEMENT OF GLUTAMIC-ACID BY VARIOUS AMINO-ACID ESTERS AND AMINES [J].

CHAYKOVSKY, M ;

BROWN, BL ;

MODEST, EJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (09) :909-912

[6] POTENTIAL FOLIC ACID ANTAGONISTS .4. SYNTHETIC APPROACHES TO ANALOGS OF AMINOPTERIN AND METHOTREXATE .4. PREPARATION OF PARA-([(2,4-DIAMINO-6-PTERIDINYL)METHYL]AMINO)-BENZOIC ACIDS [J].

ELLIOTT, RD ;

TEMPLE, C ;

MONTGOMERY, JA .

JOURNAL OF ORGANIC CHEMISTRY, 1970, 35 (05) :1676-+

[7] SYNTHESE VON PEPTIDEN MIT DER AMINOSAURESEQUENZ 1-10 DES CORTICOTROPINS [J].

GEIGER, R ;

STURM, K ;

SIEDEL, W .

CHEMISCHE BERICHTE-RECUEIL, 1963, 96 (04) :1080-+

[8] DIHYDROFOLATE REDUCTASE FROM AMETHOPTERIN-RESISTANT LACTOBACILLUS-CASEI [J].

GUNDERSEN, LE ;

HARDING, NGL ;

FREISHEIM, JH ;

OTTING, F ;

HUENNEKENS, FM ;

DUNLAP, RB .

BIOCHEMISTRY, 1972, 11 (06) :1018-+

[9]

HAMADA Y, 1977, CHEM PHARM BULL, V25, P221

[10] ACCUMULATION OF METHOTREXATE DIGLUTAMATE IN HUMAN LIVER DURING METHOTREXATE THERAPY [J].

JACOBS, SA ;

DERR, CJ ;

JOHNS, DG .

BIOCHEMICAL PHARMACOLOGY, 1977, 26 (23) :2310-2313

← 1 2 3 →