DRUGS AS ALLERGENS - AN IMMUNOASSAY FOR DETECTING IGE ANTIBODIES TO CEPHALOSPORINS

被引：52

作者：

HARLE, DG

BALDO, BA

机构：

[1] ROYAL N SHORE HOSP, KOLLING INST MED RES, ST LEONARDS, NSW 2065, AUSTRALIA

[2] UNIV SYDNEY, DEPT MED, SYDNEY, NSW 2006, AUSTRALIA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 92卷 / 04期

关键词：

D O I：

10.1159/000235177

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A radioimmunoassay employing cephalothin linked to a solid phase has been developed for the detection of cephalosporin-reactive IgE antibodies. Direct binding and inhibition studies demonstrated allergenic cross-reactivity between cephalosporins and penicillins, and quantitative hapten inhibition experiments identified the 2-thiophene group, and particularly the attached methylene group, of cephalothin as an allergenic determinant.

引用

页码：439 / 444

页数：6

共 16 条

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HARLE, DG
BALDO, BA
SMAL, MA
FISHER, MM
[J]. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1987, 84 (03): : 277 - 283
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