EFFECTS OF REPEATED TREATMENT WITH 1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE (DOI) ON THE AUTOREGULATORY CONTROL OF DORSAL RAPHE 5-HT NEURONAL FIRING AND CORTICAL 5-HT RELEASE

被引：22

作者：

KIDD, EJ ^{[1
]}

GARRATT, JC ^{[1
]}

MARSDEN, CA ^{[1
]}

机构：

[1] QUEENS MED CTR,SCH MED,DEPT PHYSIOL & PHARMACOL,NOTTINGHAM NG7 2UH,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 200卷 / 01期

基金：

英国惠康基金;

关键词：

5-HT RELEASE INVIVO; DORSAL RAPHE NUCLEUS; 5-HT NEURONAL FIRING; DOI (1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE); 5-HT2/5-HT1A RECEPTOR INTERACTION;

D O I：

10.1016/0014-2999(91)90675-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

These experiments were designed to examine the effects of repeated 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) treatment on the autoregulatory control of cortical 5-HT release and dorsal raphe nucleus (DRN) 5-HT neuronal cell firing. Repeated DOI treatment decreased the behavioural responsiveness (wet-dog shakes) of 5-HT2 receptors and attenuated the inhibitory effects of the 5-HT1A receptor agonist, 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), on both cortical 5-HT release and DRN 5-HT neuronal firing. In contrast, the inhibitory effect of acute DOI on cortical 5-HT release and DRN 5-HT neuronal firing was unaffected by repeated DOI treatment. The results demonstrate that changes in the responsiveness of 5-HT2 receptor function may influence the responsiveness of presynaptic 5-HT1A receptors regulating 5-HT neuronal function. The results also provide further evidence that the inhibition of cortical 5-HT release and DRN 5-HT neuronal firing produced by DOI is not mediated by 5-HT2 receptor activation.

引用

页码：131 / 139

页数：9

共 48 条

[1] LYSERGIC ACID DIETHYLAMIDE - SENSITIVE NEURONAL UNITS IN MIDBRAIN RAPHE [J].

AGHAJANIAN, GK ;

FOOTE, WE ;

SHEARD, MH .

SCIENCE, 1968, 161 (3842) :706-+

[2] WET-DOG SHAKE BEHAVIOR IN RAT - POSSIBLE QUANTITATIVE MODEL OF CENTRAL 5-HYDROXYTRYPTAMINE ACTIVITY [J].

BEDARD, P ;

PYCOCK, CJ .

NEUROPHARMACOLOGY, 1977, 16 (10) :663-670

[3]

BLACKSHEAR MA, 1982, J PHARMACOL EXP THER, V221, P303

[4] EFFECTS OF THE 2 ANTIDEPRESSANT DRUGS MIANSERIN AND INDALPINE ON THE SEROTONERGIC SYSTEM - SINGLE-CELL STUDIES IN THE RAT [J].

BLIER, P ;

DEMONTIGNY, C ;

TARDIF, D .

PSYCHOPHARMACOLOGY, 1984, 84 (02) :242-249

[5] SEROTONINERGIC BUT NOT NORADRENERGIC NEURONS IN RAT CENTRAL-NERVOUS-SYSTEM ADAPT TO LONG-TERM TREATMENT WITH MONOAMINE-OXIDASE INHIBITORS [J].

BLIER, P ;

DEMONTIGNY, C .

NEUROSCIENCE, 1985, 16 (04) :949-955

[6]

BLIER P, 1983, J NEUROSCI, V3, P1270

[7] THE 5-HT1 RECEPTOR AGONIST RU-24969 DECREASES 5-HYDROXYTRYPTAMINE (5-HT) RELEASE AND METABOLISM IN THE RAT FRONTAL-CORTEX INVITRO AND INVIVO [J].

BRAZELL, MP ;

MARSDEN, CA ;

NISBET, AP ;

ROUTLEDGE, C .

BRITISH JOURNAL OF PHARMACOLOGY, 1985, 86 (01) :209-216

[8] EFFECTS OF A SELECTIVE 5-HT REUPTAKE BLOCKER, CITALOPRAM, ON THE SENSITIVITY OF 5-HT AUTORECEPTORS - ELECTROPHYSIOLOGICAL STUDIES IN THE RAT-BRAIN [J].

CHAPUT, Y ;

DEMONTIGNY, C ;

BLIER, P .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1986, 333 (04) :342-348

[9] A POSSIBLE CORRELATION BETWEEN DRUG-INDUCED HALLUCINATIONS IN MAN AND A BEHAVIOURAL RESPONSE IN MICE [J].

CORNE, SJ ;

PICKERIN.W .

PSYCHOPHARMACOLOGIA, 1967, 11 (01) :65-65

[10] INVIVO EVIDENCE THAT 5-HYDROXYTRYPTAMINE (5-HT) NEURONAL FIRING AND RELEASE ARE NOT NECESSARILY CORRELATED WITH 5-HT METABOLISM [J].

CRESPI, F ;

GARRATT, JC ;

SLEIGHT, AJ ;

MARSDEN, CA .

NEUROSCIENCE, 1990, 35 (01) :139-144

← 1 2 3 4 5 →