HYPOTHERMIA IS CRITICAL FOR SURVIVAL DURING PROLONGED INSULIN-INDUCED HYPOGLYCEMIA IN RATS

被引:40
作者
BUCHANAN, TA [1 ]
CANE, P [1 ]
ENG, CC [1 ]
SIPOS, GF [1 ]
LEE, C [1 ]
机构
[1] UNIV SO CALIF,SCH MED,DEPT MED,DIABET & METAB SECT,LOS ANGELES,CA 90033
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1991年 / 40卷 / 03期
关键词
D O I
10.1016/0026-0495(91)90118-G
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypothermia is a well-known concomitant of hypoglycemia in mammals. We tested the hypothesis that this hypothermia is an important adaptive response to hypoglycemia in 11 normal Sprague-Dawley rats. Twelve-hour fasted, conscious animals received primed, continuous insulin infusions for up to 8 hours. Plasma glucose was clamped between 30 and 40 mg/dL and core body temperature was monitored continuously during the insulin infusions. Five of the animals were maintained in a room temperature environment (22 to 24°C) during the hypoglycemia; all became hypothermic (mean ± SE nadir core temperature, 31 ± 0.5°C). Spontaneous activity was reduced in these animals, but they remained conscious and responsive to external stimuli. All five returned to normal behavior after euglycemia was restored at the end of the insulin infusions. In the remaining six animals, hypothermia was prevented during hypoglycemia by warming of the air in their cages (mean of hourly core temperatures, 37 ± 0.1°C). None of these animals survived more than 7 hours. The severity of the hypoglycemia was no greater in the euthermic than in the hypothermic group, as judged by the mean of individual nadir plasma glucose levels (25 ± 1 v 24 ± 1 mg/dl, respectively) and by the mean number of glucose values per animal that were less than 30 mg/dL (2 ± 1 v 7 ± 1). Plasma osmolality did not change significantly in either group during the period of hypoglycemia, suggesting that dehydration was not the cause of death in the euthermic animals. Our findings indicate that hypothermia is an important adaptive response that allows survival during prolonged periods of insulin-induced hypoglycemia. © 1991.
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页码:330 / 334
页数:5
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