SALIVARY-GLAND MATERIAL FROM THE SAND FLY LUTZOMYIA-LONGIPALPIS HAS AN INHIBITORY EFFECT ON MACROPHAGE FUNCTION IN-VITRO

被引：84

作者：

THEODOS, CM

TITUS, RG

机构：

[1] Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts

来源：

PARASITE IMMUNOLOGY | 1993年 / 15卷 / 08期

关键词：

LUTZOMYIA-LONGIPALPIS; SAND FLY; LEISHMANIA-MAJOR; MACROPHAGE; ANTIGEN PRESENTATION;

D O I：

10.1111/j.1365-3024.1993.tb00634.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous work from our laboratory demonstrated that the infectivity of the protozoan parasite Leishmania major was enhanced in mice if the infecting inoculum contained salivary gland lysates from the sandfly vector Lutzomyia longipalpis. The present study was designed to address the hypothesis that sand fly salivary gland material may function by inhibiting the host immune response. Results indicated that sand fly saliva inhibited the ability of macrophages to present leishmanial antigens to parasite-specific T cells.

引用

页码：481 / 487

页数：7

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