ASYMMETRIC-SYNTHESIS OF CAMPTOTHECIN ALKALOIDS - A 9-STEP SYNTHESIS OF (S)-CAMPTOTHECIN

被引：80

作者：

COMINS, DL

HONG, H

JIANHUA, G

机构：

[1] Department of Chemistry North Carolina State University, Raleigh

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)73492-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

DE Ring camptothecin intermediate II war prepared enantioselectively from 2-chloro-6 hydroxypyridine in six steps and used in a nine-step synthesis of (S)-camptothecin.

引用

页码：5331 / 5334

页数：4

共 28 条

[1] CIA JC, 1983, ALKALOIDS CHEM PHARM, V21, P101
[2] CIA JC, 1983, CHEM HETEROCYCL COMP, V25, P753
[3] A 10-STEP, ASYMMETRIC-SYNTHESIS OF (S)-CAMPTOTHECIN
COMINS, DL
BAEVSKY, MF
HONG, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (27) : 10971 - 10972
[4] LITHIATION OF METHOXYPYRIDINES DIRECTED BY ALPHA-AMINO ALKOXIDES
COMINS, DL
KILLPACK, MO
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (01) : 69 - 73
[5] EFFICIENT SYNTHESIS AND RESOLUTION OF TRANS-2-(1-ARYL-1-METHYLETHYL)CYCLOHEXANOLS - PRACTICAL ALTERNATIVES TO 8-PHENYLMENTHOL
COMINS, DL
SALVADOR, JM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (17) : 4656 - 4661
[6] ORTHO LITHIATION OF 2-METHOXYPYRIDINES, 3-METHOXYPYRIDINES, AND 4-METHOXYPYRIDINES
COMINS, DL
LAMUNYON, DH
[J]. TETRAHEDRON LETTERS, 1988, 29 (07) : 773 - 776
[7] COMINS DL, 1992, SYNLETT, P615
[8] AN EFFICIENT PREPARATION OF (+)-TRANS-2-(ALPHA-CUMYL)CYCLOHEXANOL ((+)-TCC) - A PRACTICAL ALTERNATIVE TO (+)-8-PHENYLMENTHOL
COMINS, DL
SALVADOR, JM
[J]. TETRAHEDRON LETTERS, 1993, 34 (05) : 801 - 804
[9] COMINS DL, 1993, Patent No. 5254690
[10] COMINS DL, 1993, Patent No. 5192082

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