CEFOTAXIME TWICE-DAILY VERSUS CEFTRIAXONE ONCE-DAILY - A RANDOMIZED CONTROLLED-STUDY IN PATIENTS WITH SERIOUS INFECTIONS

被引:10
作者
SIMMONS, BP [1 ]
GELFAND, MS [1 ]
GROGAN, J [1 ]
CRAFT, B [1 ]
机构
[1] METHODIST HOSP,MEMPHIS,TN
关键词
D O I
10.1016/0732-8893(95)00080-T
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
We randomized 365 patients with serious infections to treatment with either 2 g intravenously (IV) cefotaxime every 12 h or 2 g IV ceftriaxone once daily. Clinical response rates were similar in both treatment groups, with success defined as satisfactory or improved response in 107 of 124 (86.3%) evaluable patients in the cefotaxime group compared with 103 of 114 (90.4%) evaluable patients in the ceftriaxone group. Bacteriologic cure rates were also similar in the two groups (86.4% in the cefotaxime group compared with 87.0% in the ceftriaxone group). There was no statistically significant difference in the incidence of drug-related adverse events in the two groups. These results indicate that 2 g cefotaxime twice daily is as effective, both clinically and bacteriologically, as 2 g ceftriaxone once daily in serious infections caused by susceptible pathogens.
引用
收藏
页码:155 / 157
页数:3
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