THE EFFECT OF OMEPRAZOLE ON HUMAN NATURAL-KILLER-CELL ACTIVITY

被引：66

作者：

AYBAY, C

IMIR, T

OKUR, H

机构：

[1] Gazi University, Faculty of Medicine, Department of Microbiology, 06500 Beşevler, Ankara

来源：

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1995年 / 26卷 / 06期

关键词：

OMEPRAZOLE; NK; CYTOTOXICITY; CONJUGATION;

D O I：

10.1016/0306-3623(94)00301-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Omeprazole, an antiulcer drug, inhibits the gastric acid pump via blocking the parietal cell (H++K+)-ATPase. Omeprazole was also reported to have an inhibitory action on polymorphonuclear neutrophil activities. In the present study the potential effect of omeprazole on human natural killer cell (NK) activity was investigated. 2. Omeprazole decreased NK cytotoxic activity in a dose-dependent manner. 3. Degraded omeprazole showed a similar action. 4. In vitro NK inhibitory action of omeprazole and its acid-degraded form was observed at the concentrations equal and higher than 18 mu M (micromolar). 5. NK inhibitory action of omeprazole was recovered to 75% by washing away of the agent. 6. Omeprazole decreased the conjugate formation of effector and target cells by 50% at the concentration of 288 mu M.

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页码：1413 / 1418

页数：6

相关论文

共 47 条

[1] OMEPRAZOLE - LONG-TERM SAFETY [J].

ARNOLD, R ;

KOOP, H .

DIGESTION, 1989, 44 :77-86

[2] THE MECHANISMS INVOLVED IN THE ACTIVATION OF HUMAN NATURAL-KILLER CELLS BY STAPHYLOCOCCAL ENTEROTOXIN-B [J].

BANKHURST, AD ;

IMIR, T .

CELLULAR IMMUNOLOGY, 1989, 122 (01) :108-121

[3] MEMBRANE TOPOLOGY AND OMEPRAZOLE LABELING OF THE GASTRIC H+,K+-ADENOSINE-TRIPHOSPHATASE [J].

BESANCON, M ;

SHIN, JM ;

MERCIER, F ;

MUNSON, K ;

MILLER, M ;

HERSEY, S ;

SACHS, G .

BIOCHEMISTRY, 1993, 32 (09) :2345-2355

[4]

BRUNTON LL, 1990, PHARMACOL BASIS THER, P897

[5] UPTAKE OF TRITIATED-THYMIDINE BY CELLS OF THE RAT GASTRIC-MUCOSA AFTER EXPOSURE TO LOXTIDINE OR OMEPRAZOLE [J].

BURLINSON, B ;

MORRISS, S ;

GATEHOUSE, DG ;

TWEATS, DJ ;

JACKSON, MR .

MUTAGENESIS, 1991, 6 (01) :11-18

[6] STRUCTURE AND FUNCTION OF VOLTAGE-SENSITIVE ION CHANNELS [J].

CATTERALL, WA .

SCIENCE, 1988, 242 (4875) :50-61

[7] EFFECT OF INTRAVENOUS AND ORAL OMEPRAZOLE ON 24-HOUR INTRAGASTRIC ACIDITY IN DUODENAL-ULCER PATIENTS [J].

CEDERBERG, C ;

THOMSON, ABR ;

MAHACHAI, V ;

WESTIN, JA ;

KIRDEIKIS, P ;

FISHER, D ;

ZUK, L ;

MARRIAGE, B .

GASTROENTEROLOGY, 1992, 103 (03) :913-918

[8] OMEPRAZOLE - A PRELIMINARY REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC POTENTIAL IN PEPTIC-ULCER DISEASE AND ZOLLINGER-ELLISON SYNDROME [J].

CLISSOLD, SP ;

CAMPOLIRICHARDS, DM .

DRUGS, 1986, 32 (01) :15-47

[9] OMEPRAZOLE TREATMENT OF SEVERE PEPTIC DISEASE ASSOCIATED WITH ANTRAL G-CELL HYPERFUNCTION AND HYPERPEPSINOGENEMIA-I IN AN INFANT [J].

DEGIACOMO, C ;

FIOCCA, R ;

VILLANI, L ;

LICARDI, G ;

SCOTTA, MS ;

SOLCIA, E .

JOURNAL OF PEDIATRICS, 1990, 117 (06) :989-993

[10] LACK OF SENSITIVITY TO OUABAIN IN NATURAL-KILLER ACTIVITY [J].

DEMORAES, VLG ;

OLEJ, B ;

DELAROCQUE, L ;

RUMJANEK, VM .

FASEB JOURNAL, 1989, 3 (12) :2425-2429

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