Podocytes as a Target of Insulin

被引：19

作者：

Coward, Richard J. M. ^{[1
]}

Saleem, Moin A. ^{[1
]}

机构：

[1] Southmead Hosp, Acad & Childrens Renal Unit, Bristol BS10 5NB, Avon, England

来源：

CURRENT DIABETES REVIEWS | 2011年 / 7卷 / 01期

基金：

英国医学研究理事会;

关键词：

Podocytes; Diabetic nephropathy; Insulin; Glomerular filtration barrier;

D O I：

10.2174/157339911794273883

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Diabetic nephropathy (DN) presents with a gradual breakdown of the glomerular filtration barrier to protein, culminating in widespread glomerular damage and renal failure. The podocyte is the central cell of the glomerular filtration barrier, and possesses unique architectural and signaling properties guided by the expression of key podocyte specific proteins. How these cellular features are damaged by the diabetic milieu is unclear, but what is becoming increasingly clear is that damage to the podocyte is a central event in DN. Here we present accumulating evidence that insulin action itself is important in podocyte biology, and may be deranged in the pathomechanism of early DN. This introduces a rationale for therapeutic intervention to improve podocyte insulin sensitivity early in the presentation of DN.

引用

页码：22 / 27

页数：6

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