THE METABOLISM OF (+/-)-METHYLEPHEDRINE IN RAT AND MAN

被引：12

作者：

INOUE, T

SUZUKI, S

机构：

[1] National Research Institute of Police Science, Sanbancho, Chiyoda-ku, Tokyo

来源：

XENOBIOTICA | 1990年 / 20卷 / 01期

关键词：

D O I：

10.3109/00498259009046816

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Urinary metabolites of methylephedrine and their excretion after oral administration to rat and human volunteers have been studied. 2. The unchanged drug, ephedrine, norephedrine, their aromatic hydroxylated compounds and methylephedrine N-oxide were found in rat urine. The same metabolites, except the p-hydroxylated metabolites, were detected in human urine. The most abundant metabolite in rat urine was methylephedrine N-oxide, and in human urine was the unchanged drug. 3. Metabolites excreted in three days after administration of the drug to rat amounted to about 54% of the dose and those after administration to man, 70-72%. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

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页码：99 / 106

页数：8

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