STRUCTURAL CHARACTERIZATION OF A NOVEL GLYCOSYL-PHOSPHATIDYLINOSITOL FROM THE PROTOZOAN TETRAHYMENA-MIMBRES

被引：12

作者：

WEINHART, U

THOMAS, JR

PAK, Y

THOMPSON, GA

FERGUSON, MAJ

机构：

[1] UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND

[2] UNIV TEXAS,DEPT BOT,AUSTIN,TX 78713

来源：

BIOCHEMICAL JOURNAL | 1991年 / 279卷

基金：

英国惠康基金;

关键词：

D O I：

10.1042/bj2790605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A glycolipid metabolically labelled with [C-14]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Man-alpha-1-2Man-alpha-1-3Man-alpha-1-4GlcN glycan. The Tetrahymena glycolipid is structurally unique among the glycosylphosphatidylinositols that have so far been characterized, including those from several protozoan parasites of humans.

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页码：605 / 608

页数：4

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