NEURONAL LOCALIZATION OF CD38 ANTIGEN IN THE HUMAN BRAIN

被引：80

作者：

MIZUGUCHI, M

OTSUKA, N

SATO, M

ISHII, Y

KON, S

YAMADA, M

NISHINA, H

KATADA, T

IKEDA, K

机构：

[1] TOKYO INST PSYCHIAT,DEPT ULTRASTRUCT & HISTOCHEM,TOKYO,JAPAN

[2] UNIV TOKYO,DEPT PATHOL,TOKYO,JAPAN

[3] SAPPORO MED SCH,DEPT PATHOL,SAPPORO,HOKKAIDO,JAPAN

[4] NIIGATA UNIV,BRAIN RES INST,DEPT PATHOL,NIIGATA 951,JAPAN

[5] TOKYO INST TECHNOL,DEPT LIFE SCI,TOKYO 152,JAPAN

来源：

BRAIN RESEARCH | 1995年 / 697卷 / 1-2期

关键词：

CYCLIC ADP-RIBOSE; 2ND-MESSENGER SYSTEM; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; WESTERN BLOTTING; NEURON;

D O I：

10.1016/0006-8993(95)00885-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CD38 is a lymphocyte differentiation antigen which is involved in the cyclic ADP-ribose-mediated second messenger system. We provide immunochemical and immunohistochemical evidence for the expression of CD38 in the adult human brain. We used six polyclonal antibodies against synthetic CD38 polypeptides, in addition to four monoclonal antibodies already available. Brain CD38 was detectable py Western blotting after immunoaffinity Purification of the brain extracts. Immunoperoxidase staining localized CD38 immunoreactivity to the perikarya and dendrites of many neurons, such as the cerebella Purkinje cells, implying that CD38 is involved in the signal transduction within the central nervous system neurons.

引用

页码：235 / 240

页数：6

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