ANTIINFLAMMATORY ACTIVITY OF QUINAZOLINOFORMAZANS

Eight substituted quinazolonoformazans were synthesized and evaluated for anti‐inflammatory activity. The degree of protection provided by seven of these compounds, at a dose of 100 mg/kg, po, against carrageenin‐induced edema in rat paw ranged from 26 to 57%. The four active substituted quinazolonoformazans (1, 2, 6, 8), on further evaluation for antiwrithmogenic activity, provided 10–80% protection against the aconitine‐induced writhing response in mice. The ulcerogenic liabilities of two of the most active compounds were also determined. The doses producing ulcers in 50% of the treated rats (UD50) were 155 and 260 mg/kg, ip, for 2 and 8, respectively. The low toxicities possessed by these substituted quinazolonoformazans were indicated by their LD50 values which ranged from 600 to 1300 mg/kg, ip, in mice. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company