PHARMACOTHERAPY FOR POSTTRAUMATIC-STRESS-DISORDER USING PHENELZINE OR IMIPRAMINE

被引:164
作者
KOSTEN, TR
FRANK, JB
DAN, E
MCDOUGLE, CJ
GILLER, EL
机构
[1] W HAVEN VET ADM HOSP,W HAVEN,CT
[2] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510
[3] UNIV CONNECTICUT,CTR HLTH,FARMINGTON,CT 06032
关键词
D O I
10.1097/00005053-199106000-00011
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Sixty male veterans with posttraumatic stress disorder (PTSD) participated in an 8-week, randomized trial comparing phenelzine (N = 19), imipramine (N = 23), and placebo (N = 18). Mean treatment retention was better on phenelzine (7.4 weeks) than on imipramine (5.6 weeks) or placebo (5.5 weeks). By week 5, both medications significantly reduced PTSD symptoms, as assessed by the Impact of Events Scale (IES), but the 44% improvement on phenelzine was greater than the 25% improvement on imipramine. The intrusion, but not the avoidance, subscale of the IES showed significant improvement, and the initial mild to moderate depressive symptoms did not significantly improve.
引用
收藏
页码:366 / 370
页数:5
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