ESOPHAGEAL MOTOR FUNCTION AND RESPONSE TO ACID PERFUSION IN PATIENTS WITH SYMPTOMATIC REFLUX ESOPHAGITIS

Peristaltic function is apparently defective in esophagitis patients and this defect may contribute to prolonged acid exposure, promoting esophageal mucosal injury. Abnormal peristalsis may be related to the generation of reflux symptoms. Primary peristalsis and its relationship to symptoms under basal conditions and during saline and HCl perfusion was evaluated in 15 symptomatic reflux patients with gross esophagitis and 15 healthy controls. In the basal state, LES [lower esophageal sphincter] pressure (15.3 vs. 25.1 mm Hg) and peristaltic amplitude (74.2 vs. 104.8 mm Hg) were significantly lower in subjects with gastroesophageal reflux disease (GERD) (P < 0.05). During HCl perfusion, peristaltic amplitude and duration increased slightly, and peristaltic velocity slightly decreased similarly in both groups. There was no difference in the incidence of nonpropagated, segmental, or swallow-initiated simultaneous contractions, or change in resting intraesophageal pressure during HCl perfusion in control and GERD groups. Abnormal contractile amplitude was identified as a specific defect in the primary peristaltic wave of esophagitis patients but does not support a role for acid-induced motility changes in the generation of symptoms in GERD.