EXPRESSION OF SUPEROXIDE-DISMUTASE AND CATALASE IN RAT-BRAIN AS A FUNCTION OF AGE

被引：97

作者：

SEMSEI, I

RAO, G

RICHARDSON, A

机构：

[1] ILLINOIS STATE UNIV,DEPT CHEM,NORMAL,IL 61761

[2] ILLINOIS STATE UNIV,DEPT BIOL SCI,NORMAL,IL 61761

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1991年 / 58卷 / 01期

关键词：

AGING; BRAIN; GENE EXPRESSION; SUPEROXIDE DISMUTASE; CATALASE;

D O I：

10.1016/0047-6374(91)90116-H

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Active oxygen species have been proposed to be involved in the aging process of the brain, therefore alterations of the levels of enzymes involved in the defence system against free radicals and other active species could substantially influence the aging process. In this study the enzyme activities of superoxide dismutase (Cu/Zn) and catalase as well as the relative levels of their mRNA were measured in the brain of Fischer F344 rats of various ages (5-37 months old). A gradual decrease in the activity of these enzymes (21-27%) was observed with increasing age. The alterations were paralleled by a decrease (39-40%) in the relative levels of these mRNA species. Thus the decrease in the activity of superoxide dismutase and catalase appears to be due to an age-dependent change in the expression of these genes.

引用

页码：13 / 19

页数：7

共 28 条

[1] RELATIONSHIP BETWEEN AGING, DRUG-TREATMENT AND THE CEREBRAL ENZYMATIC ANTIOXIDANT SYSTEM [J].