BEHAVIOR OF AMINO-ACIDS IN GEL-PERMEATION CHROMATOGRAPHY - CORRELATION WITH THE EFFECT OF HOFMEISTER SOLUTES ON THE CONFORMATIONAL STABILITY OF MACROMOLECULES

The gel chromatographic behaviour of the twenty naturally occuring amino acids was investigated. The effect of salts ranking in the salting-out side of the Hofmeister series was studied over a wide range of concentrations. The dependence of In Kd on salt concentration was utilized to rank the amino acids in a "solvatochromic" scale which could help in predicting the propensity for regions in the polypeptide chain to be exposed to the solvent. © 1990.