RECEPTOR CLASSIFICATION USING ANTAGONISTS WITHOUT DETERMINING PA2 VALUES

被引：4

作者：

KROMER, W ^{[1
]}

机构：

[1] MED SCH HANNOVER,PHARMACOL,HANNOVER,GERMANY

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1991年 / 12卷 / 01期

关键词：

D O I：

10.1016/0165-6147(91)90482-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Albeit time-consuming, the most rigorous method of classification of receptor subtypes is the determination of pA2 values. However, this methodology requires the knowledge of absolute concentrations of both agonists and antagonists - something that may not necessarily be calculable under certain experimental conditions. Wolfgang Kromer offers a different method for classification using antagonists which is not dependent on absolute affinities, and which has the additional advantage of speed.

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页码：11 / 13

页数：3

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