EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA) RECEPTORS, TGF-BETA-1 AND TGF-BETA-2 PRODUCTION AND AUTOCRINE GROWTH-CONTROL IN OSTEOSARCOMA CELLS

被引：37

作者：

KLOEN, P ^{[1
]}

JENNINGS, CL ^{[1
]}

GEBHARDT, MC ^{[1
]}

SPRINGFIELD, DS ^{[1
]}

MANKIN, HJ ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT ORTHOPED SURG,ORTHOPED RES LABS,BOSTON,MA 02114

来源：

INTERNATIONAL JOURNAL OF CANCER | 1994年 / 58卷 / 03期

关键词：

D O I：

10.1002/ijc.2910580323

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transforming growth factor-beta (TGF-beta) is a polypeptide with multiple physiological functions. Isoforms of this growth factor have important roles in control of the cell cycle, in regulation of cell-cell interactions and in growth and development. Malignant transformation has been shown to be associated with increased expression of TGF-beta. Since bone is the largest storage site and producer of TGF-beta, we speculated on the existence of an autocrine mechanism in osteosarcoma, a malignant bone tumor. Expression of TGF-beta cell surface receptors, effects on growth of TGF-beta and TGF-beta antibodies and production of 2 TGF-beta isoforms were studied in a panel of 7 osteosarcoma cell lines. In contrast to most previous reports on the effects of TGF-beta on osteosarcoma cell growth, we found a mitogenic effect of TGF-beta 1 in 4 of 7 osteosarcoma cell lines. Receptor profiles for TGF-beta were aberrant in 5 of the 7 cell lines tested, and production of TGF-beta 1 and TGF-beta 2 varied among cell lines. Addition of anti-TGF-beta antagonized the effects of endogenous TGF-beta. Our results suggest a potential role of TGF-beta in autocrine growth control of osteosarcoma cells. (C) 1994 Wiley-Liss, Inc.

引用

页码：440 / 445

页数：6

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