INTRANEURONAL LAMININ-LIKE IMMUNOREACTIVITY IN THE HUMAN CENTRAL-NERVOUS-SYSTEM

被引：22

作者：

SUZUKI, H

YAMAMOTO, T

YAMAMOTO, H

KONNO, H

IWASAKI, Y

OHARA, Y

TERUNUMA, H

机构：

[1] FUKUSHIMA MED SCH,DEPT NEUROL,FUKUSHIMA 960,JAPAN

[2] NORTHWESTERN UNIV,SCH MED,DEPT CELL MOLEC & STRUCT BIOL,CHICAGO,IL 60611

来源：

BRAIN RESEARCH | 1990年 / 520卷 / 1-2期

关键词：

Extracellular matrix; Human brain; Immunocytochemistry; Laminin; Trophic factor glycoprotein;

D O I：

10.1016/0006-8993(90)91723-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Because laminin possesses potent neurotrophic activity, laminin-like immunoreactivity was investigated in formalin-fixed human brains, using affinity-purified anti-human placental laminin rabbit serum. Distinct laminin-like immunoreactivity was observed in neuronal soma of certain nuclear groups, and a 180-kDa band was noted in an immunoblot study of the supernatant of brain homogenate. These observations imply that many but not all central neurons have laminin-like immunoreactive molecules. Their functional role, however, remains to be clarified. © 1990.

引用

页码：324 / 329

页数：6

共 27 条

[1] ASTROCYTES SECRETE BASAL LAMINA AFTER HEMISECTION OF RAT SPINAL-CORD [J].